Endocrine Abstracts

The case: The case described is a 49 year old lady referred to emergency department with history of episodic palpitations, headache and sweating with possible weight loss for last 14 years but symptoms now worse in the past few days. Past medical history was significant for modest hypertension with retinal changes treated with Lisinopril. Patient stopped going to the gym recently as it seemed to exacerbate the symptoms. Patient recently registered with a new GP who in view of ...

Adult male rhesus monkeys (Macaca mulatta) were given oral treatment of either Aroclor 1242 or vehicle (corn oil and glycerol) at a dose of 200 microgram/kg bw/day/animal for six months to investigate the effect of pollutant on plasma testosterone and morphology of testis and accessory glands. The animals used in this research have been treated humanely according to institutional guidelines, with due consideration to the alleviation of distress and discomfort. Aroclor 1242 tre...

27-year-old male presented to the outpatient adult Endocrine team with Classical Salt wasting CAH due to 21 -Hydroxylase Deficiency. He has 659 A/C G splice mutation. There was no prior family history of CAH. The diagnosis was made at birth and he was commenced on hydrocortisone and Fludrocortisone. Further confirmatory tests were done at the age of one month. He was regularly followed up in the pediatric endocrine clinic. There have always been issues with compliance. He had ...

Adrenal gland is a less focused endocrine organ for the endocrine disrupting effect of endocrine disrupting chemicals (EDCs). The effects of two extensively used phthalate esters viz. di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on adrenal gland were observed in Wistar rats in the present study to check the susceptibility of adrenal gland against the exposure of these extensively used plasticizers which are well known EDCs. Wistar rats were divided into seven g...

A 70-year old female patient was referred to the Endocrine clinic after incidental finding of significant hypercalcaemia (3.19 mmol/l, NR: 2.20-2.60 mmol/l) during work-up for cognitive decline. She had a known background of T2DM, hyperlipidaemia, osteoarthritis with a previous right total hip replacement and a laparoscopic cholecystectomy. She was first reviewed in clinic in June 2022 and was almost asymptomatic, except for memory issues. She denied previous history of renal ...

Graves’ disease (GD) is the most common cause of hyperthyroidism1 and is caused by stimulating autoantibodies to the TSH receptor (TRAb).2 TRAb assays have 98% sensitivity and 99% specificity 3 for GD and are recommended as the first-line cost-effective investigation to diagnosis the aetiology of hyperthyroidism and determine the risk of thyroid eye disease.4,5 In TRAb antibody negative patients, radionuclide imaging may be help...

Background: The principal cause for increased osteoporosis risk in young adults is the underlying endocrine condition that can severely compromise the prime bone building stage occurring during adolescence. As this could lead to a diminished quality of life from a relatively early stage, emphasis lies on correcting the endocrine condition with appropriately tailored management that can prevent its deterioration. Examples of treatments include replacing deficit hormones such as...

Pancreatic Neuroendocrine tumours, P-NETs, comprise 2–3% of all pancreatic tumours. Usually classified as functional or non-functional based on whether these secrete biologically active amines, causing specific syndromes or not. Even non-functional P-NETs in majority of cases secrete substances, not associated with any specific syndrome, like Chromogranin A and Chromogranin B and Pancreatic Polypeptide (PP). An estimated 2% of all the neuroendocrine tumours secrete Pancre...

A 74 years old man was referred to endocrine clinic with abnormal TFTs with raised free T4 (39.7 pmol/l; NR: 7.0–17 pmol/l), raised FT3 (7.3 pmol/l; NR: 3.5–6.5 pmol/l) and normal TSH (1.9 mU/ml; NR: 0.35–5.5 mU/ml) which were done on routine testing by his GP. PMH included COPD and B12 deficiency. He had no symptoms suggestive of thyrotoxicosis and was clinically euthyroid. Investigations were arranged to exclude the three possibilities of assay interference, R...

Background: Endometriosis is a common disease in women and considered as one of the most important reasons infertility, and it means abnormal growth of the endometrial tissue outside of the uterine. The exact prevalence of endometriosis disease is unknown. estimated that the endometriosis exists in 10% of women in productivity. Possibly, several genes interacting with each other as well as environment to result endometriosis. Given that one of the cellular pathways involved in...